I'm having the exact same problem. The pointer hotspot keeps moving and is most often in the middle of the pointer. Replacing the mouse with a brand new Microsoft Laser Mouse with the latest drivers did not fix the problem, nor did turning off the Aero interface. This is on a new Dell XPS desktop that came with Vista installed. I also have a 6 month old Inspiron laptop with the same version of Vista that does not exhibit this behavior either with the touchpad or a bluetooth wireless mouse. Anybody have any more info on this problem?